Long-Term Study Finds Lifestyle Intervention Reduces Risk of Multiple Chronic Diseases in Adults with Prediabetes. New findings show lifestyle changes were linked to lower multimorbidity risk over 21 years.

A long-term study of adults with prediabetes showed that lifestyle changes were tied to a lower risk of multimorbidity, but metformin was not. Regardless of treatment group, over 80% of all participants developed at least two chronic conditions over time..

What Beats the Biohacking Drug Metformin for Healthy Aging?

An NIH-backed study tracking older adults with prediabetes for over 20 years found that intensive lifestyle changes cut the risk of developing multiple chronic conditions by up to 25%. In contrast, taking the diabetes medication metformin provided no significant reduction.

The October 2025 issue of Diabetes Care included a special collection of DPP/DPPOS papers to celebrate DPP's 30th anniversary (1995-2025).The special collection includes five papers representing a range of topics.

Dr. Steven Kahn was awarded the Banting Medal for Scientific Achievement at the 85th Scientific Sessions. His Banting Award lecture, “Revisiting the β-cell: The Key to the Type 2 Diabetes Puzzle” was featured during the ADA Meeting.

DPPOS was recently highlighted in the American Diabetes Association’s Diabetes Care NIDDK 75th Anniversary Collection. The article outlines the important contributions of DPPOS.