Learn more about the Diabetes Prevention Program and Outcomes Study: 

Background

"Twenty years ago, many people assumed getting diabetes was just part of getting older and felt powerless to do anything about it. DPP changed that. It helped focus more attention on diabetes and, most importantly, proved that it is not inevitable. As we now know, type 2 diabetes can be prevented or delayed in many cases. DPP is is the largest and longest trial sponsored by the National Institutes of Health that showed how we might actually reverse this worldwide epidemic," David Nathan, M.D.

Timeline

 

The DPP/DPPOS chronology is as follows:

1996-1999    

DPP screening and randomization.

2001    

DPP stopped one-year ahead of schedule in 2001 on the advice of the Data Monitoring Board due to statistically significant and clinically compelling decrease in the development of diabetes in the lifestyle intervention and metformin-treated groups.

2001-2002    

DPP Bridge: Metformin washout study and lifestyle training for all participants.

2002    

DPPOS was funded for a five-year period ("DPPOS Phase I") with the understanding that completion of the originally-proposed 10-year study would require re-funding via competitive renewal.

2004    

NIDDK administratively approved an additional year, recognizing that analysis of five-year data in a study of this size would require an additional year.

2009    

NIDDK awarded funding for the second 5 years of the 11-year study ("DPPOS Phase 2"), based on a rigorous competitive renewal process.

2011    

NIDDK administratively approved an additional year prior to submitting a non-competing continuation.

Oct 2013    

Scheduled end of DPPOS primary outcome assessments for Phase 2.

Jan 2015    

Scheduled end of DPPOS Phase 2 funding.

 

 

Research Group
Information for each clinical site and research core is listed under Research Group.

Program Staff Only: To access the research group website, please click here.

     

DPPOS Coordinating Center
George Washington University Biostatistics Center
6110 Executive Blvd. Suite 750
Rockville, MD 20852
dppmail@bsc.gwu.edu

     

Technical Support
Please contact the DPPOS webmaster with any problems with login or accessing documents from the website.